Identified only as Nhyira, nine months old and Vanessa, two years, the children were said to be sleeping when their house was caught up in flames last Monday.
Their mother, who is believed to be a health worker at the Offinso Health Centre, managed to escape from the house but she is yet to be located.
Her disappearance has since made it difficult for personnel of the Ghana National Fire Service (GNFS) at Offinso to investigate the matter.
The remains of the two kids have been deposited at the morgue for autopsy.
Cause of fire
The cause of the fire has not been ascertained but some eye witnesses have attributed it to a suspected electrical fault.
In separate interviews, they said it was around 10 p.m. last Monday when they heard the mother of the kids screaming for help.
The Acting Offinso Municipal Fire Officer, Assistant Divisional Officer (ADO) II, Mr K.E. Glalah, who briefed the Daily Graphic, said the GNFS received a distress call at around 11:16 p.m. last Monday that a house had caught fire at Twemasen in Offinso.
He said upon arrival at the scene, the fire had already engulfed the boys’ quarters attached to a six-bedroom house.
Mr Glalah said with the help of personnel from the Offinso office of the National Disaster Management Organisation (NADMO) and residents, the fire was brought under control before the remains of the deceased could be retrieved.
He said the GNFS was investigating the matter.